Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis

Objectives To investigate the effects of lactitol on intestinal flora and the levels of plasma endotoxin in patients with chronic viral hepatitis. Methods Sixty patients with chronic viral hepatitis and gut-derived endotoxemia were randomly divided into two groups: lactitol group (n = 30) and control group (n = 30). Patients in the control group received[…]

High levels of antibiotic resistance found worldwide, new data shows

29 January 2018 | BANGKOK – WHO’s first release of surveillance data on antibiotic resistance reveals high levels of resistance to a number of serious bacterial infections in both high- and low-income countries. WHO’s new Global Antimicrobial Surveillance System (GLASS) reveals widespread occurrence of antibiotic resistance among 500 000 people with suspected bacterial infections across[…]

Are Oral Peptide Drugs on the Horizon?

By Randi Hernandez Peptides and proteins generally have low bioavailability when taken by mouth, and this hurdle has generally prevented the oral delivery of many biologic drugs in the past. However, plant cell walls may be ideal transporters to move protein-based drugs through the digestive system without the drugs being exposed to degradation by stomach[…]

FDA Approves Once-Daily Jentadueto XR (linagliptin and metformin hydrochloride extended-release) for Type 2 Diabetes

Ridgefield, Conn., and Indianapolis, May 31, 2016 – The U.S. Food and Drug Administration (FDA) has approved Jentadueto XR (linagliptin and metformin hydrochloride extended-release) tablets for the treatment of type 2 diabetes (T2D) in adults. Jentadueto XR, which is marketed by Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY), is the seventh new treatment[…]